重組人胰島素樣生長(cháng)因子-Ⅰ, IGF-Ⅰ

貨號:

100-12

品牌:

Peprotech

規格:

20μg

概述

Insulin-like Growth Factor-II, Somatamedin A

研究領(lǐng)域:

細胞生物學(xué)

詳述

The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissuein vitro.? IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times.? The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. ?The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin.? IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone.? Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor.? Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.? Recombinant Human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.? The calculated molecular weight of Recombinant Human IGF-II is 7.5 kDa.

氨基酸序列:

AYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVSRRSR GIVEECCFRS CDLALLETYC ATPAKSE

來(lái)源:

E.coli

純度:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

生物活性:

The?ED₅₀?was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10⁵?units/mg.

交叉反應:

Mouse, Rat, Salamander, Human

儲存與安全

儲存:

2℃~8℃

關(guān)于我們

Wolcavi Biotech致力于干細胞免疫治療、分子生物學(xué) 、免疫學(xué)、體外診斷等相關(guān)領(lǐng)域的實(shí)驗需求產(chǎn)品開(kāi)發(fā)和銷(xiāo)售。主要產(chǎn)品有抗原抗體|無(wú)血清培養基|細胞培養耗材并代理銷(xiāo)售Abcam、Invitrogen(Gibco)、Roche、Sigma、R&D、Meridian等二十多家國外知名品牌。

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重組人胰島素樣生長(cháng)因子-Ⅰ, IGF-Ⅰ