Recombinant Human Noggin

貨號:

120-10C

品牌:

Peprotech

規格:

20μg

概述

研究領(lǐng)域:

細胞生物學(xué)

詳述

Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β family, and regulate their activity by inhibiting their access to signaling receptors.? The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule.? Noggin was originally identified as a BMP-4 antagonist whose action was critical for proper formation of the head and other dorsal structures.? Consequently, noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14.? Targeted deletion of Noggin in mice results in prenatal death, and a recessive phenotype displaying a severely malformed skeletal system.? Conversely, transgenic mice over-expressing noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.? Recombinant Human Noggin is a 46 kDa disulfide-linked homodimer consisting of two 205 amino acid polypeptide chains.? Monomeric glycosylated noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions.

氨基酸序列:

QHYLHIRPAP SDNLPLVDLI EHPDPIFDPK EKDLNETLLR SLLGGHYDPG FMATSPPEDR PGGGGGAAGG AEDLAELDQL LRQRPSGAMP SEIKGLEFSE GLAQGKKQRL SKKLRRKLQM WLWSQTFCPV LYAWNDLGSR FWPRYVKVGS CFSKRSCSVP EGMVCKPSKS VHLTVLRWRC QRRGGQRCGW IPIQYPIISE CKCSC

來(lái)源:

HEK293 cells

純度:

Greater than 95% by SDS-PAGE gel and HPLC analyses.

生物活性:

Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC chondrogenic cells. The expected?ED₅₀?for this effect is 2.0-3.0 ng/ml of Noggin.

交叉反應:

Chicken, Mouse, Human

儲存與安全

儲存:

2-8℃保存

關(guān)于我們

Wolcavi Biotech致力于干細胞免疫治療、分子生物學(xué) 、免疫學(xué)、體外診斷等相關(guān)領(lǐng)域的實(shí)驗需求產(chǎn)品開(kāi)發(fā)和銷(xiāo)售。主要產(chǎn)品有抗原抗體|無(wú)血清培養基|細胞培養耗材并代理銷(xiāo)售Abcam、Invitrogen(Gibco)、Roche、Sigma、R&D、Meridian等二十多家國外知名品牌。

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Phone: +86 010 8646 3560
Email: info@wolcavi.com

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標簽

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010-5944 6861

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Recombinant Human Noggin